Show all Biopharmaceuticals

Biopharmaceuticals are substances produced with biotechnology (using live cells), harvested from living organisms. Their high efficacy makes them the future of modern pharmacotherapy.

Biopharmaceuticals and xenobiotics

What are the differences between pharmaceuticals produced via chemical synthesis and stem cell-based biopharmaceuticals? Why is the efficacy and safety of novel therapies superior to traditional ones?

 

Xenobiotics

  • Steroidal anti-inflammatory drugs (SAIDs) and non-steroidal anti-inflammatory drugs (NSAIDs) are xenobiotics – chemical compounds produced via chemical synthesis which do not occur naturally in mammals.
  • Their constituent substances include steroidal anti-inflammatory drugs (SAIDs) and non-steroidal anti-inflammatory drugs (NSAIDs).
  • Treatment with SAIDs and NSAIDs is symptomatic, limited to reducing inflammation and reducing pain – they are not designed to induce regenerative processes.
  • When used against conditions caused by underlying chronic inflammation they exhibit a singular mechanism of action such as COX-2 enzyme inhibition. This alleviates inflammation, but also causes adverse reactions (e.g. gastrointestinal microbleeds), and the chronic drug use required by the treatment raises the likelihood of such reactions to a significant level.
  • Their long-term use for chronic osteoarthritis may cause numerous adverse reactions, including Cushing’s syndrome, muscle atrophy, hepatitis or ulceration of gastric mucosa.

Stem cell-based biopharmaceuticals

  • Stem cell-based biopharmaceuticals bring new quality and technological challenges at the manufacturing and quality control stages: due to its complexity, the entire production is under continuous monitoring, while quality control requires advanced analytical methods.
  • Mesenchymal stem cells (MSCs) serve as the active pharmaceutical ingredient – a viable alternative to steroidal and non-steroidal anti-inflammatory drugs.
  • Through their immunomodulatory effect, MSCs induce natural pathways of intracellular signal transduction, having a strong anti-inflammatory, analgesic and pro-regenerative effect.
  • MSCs are a long acting API, and their therapeutic effect is based on stimulating the natural processes of the body – they cause none of the adverse reactions associated with chronic anti-inflammatory drug use.
  • The key property of stem cells used in therapy is their capacity to actively support the regeneration of damaged tissue.

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